Author

Z.-N. Chen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:proteomics· 1

Frequent Co-Authors

D. Wei· 2 shared H. Bian· 2 shared K. Wang· 2 shared K. Zhang· 2 shared P. Du· 2 shared P. Zhu· 2 shared T. Guo· 2 shared X. Yang· 2 shared

Activity by Year

2020-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersImmunology

D. Wei

Mutual co-authors in cluster

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2 papers

Recent·Most cited

CD147 antibody specifically and effectively inhibits infection and cytokine storm of SARS-CoV-2 variants

Z.-N. Chen, P. Zhu, H. Bian, J. Geng, L. Chen, Y. Yuan, R. Chen, K. Wang, Y. Deng, P. Du, J. Liu, G. Wu, Y. Wang, X. Sun, T. Guo, , Y. Li

This study shows that CD147 antibody inhibits SARS-CoV-2 infection and cytokine storm in variants by blocking viral entry and reducing inflammatory responses.

bioRxiv · May 14, 2021Immunology

SARS-CoV-2 invades host cells via a novel route: CD147-spike protein

K. Wang, W. Chen, Y.-S. Zhou, J.-Q. Lian, Z. Zhang, P. Du, L. Gong, Y. Zhang, H.-Y. Cui, J.-J. Geng, B. Wang, X.-X. Sun, C.-F. Wang, X. Yang, P. Lin, , Z.-N. Chen

This study identifies CD147 as a novel receptor for SARS-CoV-2 spike protein, showing that Meplazumab inhibits viral entry with EC50 24.86 g/mL and confirms the interaction through binding assays and microscopy.

bioRxiv · Mar 14, 2020Microbiology