Homeodomain-interacting protein kinase maintains neuronal homeostasis during normal Caenorhabditis elegans aging and systemically regulates longevity from serotonergic and GABAergic neurons
María I. Lázaro‐Peña, Adam B. Cornwell, Carlos A. Díaz-Balzac, Ritika Das, Zachary C. Ward, Nicholas Macoretta, Juilee Thakar, Andrew V. Samuelson
This study identifies HPK-1 as a neuronal transcriptional regulator that maintains proteostasis and extends longevity in C. elegans by modulating serotonergic and GABAergic pathways.
eLife · Jun 20, 2023Peer-reviewedGenetics