Andrew V. Samuelson

This study shows that aging in C. elegans reduces antiviral defense by impairing DRH-1 deSUMOylation via ULP-4, leading to loss of the intracellular pathogen response.

This study identifies the transcriptional response to dietary restriction in C. elegans and shows that MML-1::MXL-2 and PHA-4 have distinct roles in mediating the physiological benefits of DR.

This study identifies HPK-1 as a neuronal transcriptional regulator that maintains proteostasis and extends longevity in C. elegans by modulating serotonergic and GABAergic pathways.

This study identifies HPK-1 as a neuronal regulator of proteostasis that delays aging through distinct serotonergic and GABAergic pathways.