Author

Adam B. Cornwell

University of Rochester MedicineORCID 0000-0002-0572-3107Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 2 Cell Biology· 1

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Research Focus:differential expression· 3 Assay:bulk RNA-seq· 2 Organism:C. elegans· 2 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

Andrew V. SamuelsoniD· 2 shared Juilee ThakariD· 2 shared Aditya BarveiD· 1 shared Akshay SharmaiD· 1 shared Carlos A. Díaz-BalzaciD· 1 shared David D. SpenceiD· 1 shared David W. Johnson· 1 shared Dirk LoeffleriD· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersGenetics

Andrew V. SamuelsonORCID

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3 papers

Recent·Most cited

Senolytics Restore Hematopoietic Stem Cells Function in Sickle Cell Disease

Aditya Barve, Adam B. Cornwell, Pramika Sriram, Oleg V. Kopyov, Preeti Dabas, Emilia Kooienga, Zakiya Kelley, James D. Johnson, Jacquelyn Myers, Esther A. Obeng, Guolian Kang, Yunusa Olufadi, Terri L. Cain, Lindsay Jones Talbot, David D. Spence, , Shannon McKinney‐Freeman

This study shows senolytics like ABT-263 restore bone marrow function in sickle cell disease by reversing HSC dysfunction and senescence in mice.

bioRxiv · Feb 8, 2025 · PreprintCell Biology

The C. elegans Myc-family of transcription factors coordinate a dynamic adaptive response to dietary restriction.

Adam B. Cornwell, Yun Zhang, Manjunatha Thondamal, David W. Johnson, Juilee Thakar, Andrew V. Samuelson

This study identifies the transcriptional response to dietary restriction in C. elegans and shows that MML-1::MXL-2 and PHA-4 have distinct roles in mediating the physiological benefits of DR.

GeroScience · Jun 15, 2024Peer-reviewedGenetics

Homeodomain-interacting protein kinase maintains neuronal homeostasis during normal Caenorhabditis elegans aging and systemically regulates longevity from serotonergic and GABAergic neurons

María I. Lázaro‐Peña, Adam B. Cornwell, Carlos A. Díaz-Balzac, Ritika Das, Zachary C. Ward, Nicholas Macoretta, Juilee Thakar, Andrew V. Samuelson

This study identifies HPK-1 as a neuronal transcriptional regulator that maintains proteostasis and extends longevity in C. elegans by modulating serotonergic and GABAergic pathways.

eLife · Jun 20, 2023Peer-reviewedGenetics