SMARCAL1 is a candidate therapeutic target for ALT-positive tumors
Angelo Taglialatela, Jina Lee, Benura Azeroglu, Xiao Chen, Maria Rosaria Dello Stritto, Antoine Gougé, Tomás Lama-Díaz, Alina Vaitsiankova, Giuseppe Leuzzi, Filemon S. Dela Cruz, Zahra F. Khan, Andrew L. Kung, Petr Ćejka, Eros Lazzerini Denchi, Jaewon Min, Alberto Ciccia
The paper identifies SMARCAL1 as a key regulator of ALT metabolism and a potential therapeutic target for ALT-positive tumors.
bioRxiv · Feb 16, 2026Cancer Biology