Angelo Taglialatela

This study uses Cas12a-based knockout screens to identify genetic interactions in the DNA damage response, revealing synthetic lethal and buffering interactions with therapeutic implications.

The paper identifies SMARCAL1 as a key regulator of ALT metabolism and a potential therapeutic target for ALT-positive tumors.

This study identifies two distinct mechanisms for generating C- and G-circles in ALT cancers, involving different origins and initiation processes for each type of extrachromosomal telomere DNA.

CRISPRmap enables multi-omic optical pooled screens to map gene function in cells and tissue without sequencing, identifying pathogenic mutations and analyzing spatial phenotypes.

This study identifies MCM8IP as a DNA repair factor that promotes homologous recombination and DNA synthesis in response to DNA damage by interacting with MCM8-9 and RPA1.