Tomás Lama-Díaz

Mapping the genetic landscape of the DNA damage response with Cas12a-based combinatorial knockout screens

This study uses Cas12a-based knockout screens to identify genetic interactions in the DNA damage response, revealing synthetic lethal and buffering interactions with therapeutic implications.

SMARCAL1 is a candidate therapeutic target for ALT-positive tumors

The paper identifies SMARCAL1 as a key regulator of ALT metabolism and a potential therapeutic target for ALT-positive tumors.

Concurrent D-loop cleavage by Mus81 and Yen1 yields half-crossover precursors

The paper shows that Mus81 and Yen1 cleave D-loops to form half-crossover precursors in budding yeast.

Alternative translation initiation by ribosomal leaky scanning produces multiple isoforms of the Pif1 helicase

The paper shows that ribosomal leaky scanning generates multiple Pif1 helicase isoforms in budding yeast through alternative translation initiation from two consecutive AUG codons.