Jaewon Min

The function of human PIF1 in G quadruplex formation and replication stress response at ALT telomeres

This study investigates the role of human PIF1 in ALT telomere maintenance, showing its involvement in DNA damage, G4 formation, and replication stress response, with implications for cancer therapy.

SMARCAL1 is a candidate therapeutic target for ALT-positive tumors

The paper identifies SMARCAL1 as a key regulator of ALT metabolism and a potential therapeutic target for ALT-positive tumors.

Distinct mechanisms underlying extrachromosomal telomere DNA generation in ALT cancers

This study identifies two distinct mechanisms for generating C- and G-circles in ALT cancers, involving different origins and initiation processes for each type of extrachromosomal telomere DNA.

Mechanisms of insertions at a DNA double-strand break

The paper develops Indel-Seq to study insertion mechanisms at DNA double-strand breaks, finding insertions arise from transcription and require DNA-PK and ssDNA overhangs.