Targeting IDH1-Mutated Oligodendroglioma with Acid Ceramidase Inhibitors
Helena Muley, Tyrone Dowdy, Faris Zaibaq, George Karadimov, Aiguo Li, Hua Song, Meili Zhang, Wei Zhang, Zalman Wong, Laurence Zhang, Adrian Lita, Mioara Larion
This study shows that inhibiting acid ceramidase (AC) induces apoptosis and improves survival in IDH1-mutated oligodendroglioma by increasing ceramide levels and activating both extrinsic and intrinsic apoptosis pathways.
bioRxiv · Apr 27, 2024 · PreprintCancer Biology