Mioara Larion

Resolving Challenges in Detection and Quantification of D-2-hydroxyglutarate and L-2-hydroxyglutarate via LC/MS

This paper develops a high-throughput HR-QTOF-LC/MS method to accurately quantify D-2HG and L-2HG enantiomers, enabling better understanding of their roles in disease.

Label-Free Live Cell Type Prediction by Integrating Raman Spectroscopy and Machine Learning

This paper uses Raman spectroscopy and machine learning to classify brain tumor cell types at single-cell resolution, achieving high accuracy in distinguishing IDH1 mutation status and histological subtypes.

SCD1 inhibition synergizes with TMZ to improve IDH1 MUT glioma survival of mice via lipotoxic stress

This paper shows that inhibiting SCD1 with MF-438 enhances TMZ effectiveness in IDH1-mutant glioma mouse models by inducing lipotoxic stress and ferroptosis.

APOE4 and INPP5D converge on membrane mechanics to regulate endocytosis in human astrocytes

This study shows APOE4 impairs endocytosis in astrocytes by altering membrane mechanics, and INPP5D restores this process by promoting clathrin curvature and maturation.

Triglyceride metabolism controls inflammation and APOE4-associated disease states in microglia

This study shows that triglyceride metabolism is essential for microglial activation and disease states in APOE4 microglia, with implications for modulating immune responses.

Targeting IDH1-Mutated Oligodendroglioma with Acid Ceramidase Inhibitors

This study shows that inhibiting acid ceramidase (AC) induces apoptosis and improves survival in IDH1-mutated oligodendroglioma by increasing ceramide levels and activating both extrinsic and intrinsic apoptosis pathways.

Targeting the sphingolipid rheostat in IDH1mut glioma alters cholesterol homeostasis and triggers apoptosis via membrane degradation

This study shows that altering sphingosine levels in IDH1mut glioma cells disrupts cholesterol homeostasis, leading to apoptosis through effects on cholesterol synthesis, uptake, and efflux.

DMT1 contributes to MF- 438 - mediated inhibition of glioma cells

The paper shows MF-438 inhibits glioma growth through both SCD1-dependent lipid metabolism disruption and SCD1-independent DMT1 suppression.