Adrian Lita

This paper uses Raman spectroscopy and machine learning to classify brain tumor cell types at single-cell resolution, achieving high accuracy in distinguishing IDH1 mutation status and histological subtypes.

This paper shows that inhibiting SCD1 with MF-438 enhances TMZ effectiveness in IDH1-mutant glioma mouse models by inducing lipotoxic stress and ferroptosis.

This study shows APOE4 impairs endocytosis in astrocytes by altering membrane mechanics, and INPP5D restores this process by promoting clathrin curvature and maturation.

This study shows that triglyceride metabolism is essential for microglial activation and disease states in APOE4 microglia, with implications for modulating immune responses.

This study shows that inhibiting acid ceramidase (AC) induces apoptosis and improves survival in IDH1-mutated oligodendroglioma by increasing ceramide levels and activating both extrinsic and intrinsic apoptosis pathways.

This study shows that altering sphingosine levels in IDH1mut glioma cells disrupts cholesterol homeostasis, leading to apoptosis through effects on cholesterol synthesis, uptake, and efflux.