SCD1 inhibition synergizes with TMZ to improve IDH1 MUT glioma survival of mice via lipotoxic stress
Laurence Zhang, Tomohiro Yamasaki, Viney Kumar, Taylor A. Harmon, Helena Muley, Meili Zhang, D. S. Davis, Samarth Mathur, Ross G. Lake, Christel Herold Mende, Tyrone Dowdy, Adrian Lita, Mioara Larion
This paper shows that inhibiting SCD1 with MF-438 enhances TMZ effectiveness in IDH1-mutant glioma mouse models by inducing lipotoxic stress and ferroptosis.
bioRxiv · Jun 12, 2026 · PreprintCancer Biology