Meili Zhang

This study identifies Gpr149 as an endogenous antigen in SB28 glioblastoma that can be targeted by vaccination to induce protective immunity against checkpoint inhibitor-refractory tumors.

This study shows that viral vector vaccination induces brain-resident memory T cells that effectively combat glioblastoma, offering a potential therapeutic strategy.

This paper shows that inhibiting SCD1 with MF-438 enhances TMZ effectiveness in IDH1-mutant glioma mouse models by inducing lipotoxic stress and ferroptosis.

This study shows that inhibiting acid ceramidase (AC) induces apoptosis and improves survival in IDH1-mutated oligodendroglioma by increasing ceramide levels and activating both extrinsic and intrinsic apoptosis pathways.

This study shows that altering sphingosine levels in IDH1mut glioma cells disrupts cholesterol homeostasis, leading to apoptosis through effects on cholesterol synthesis, uptake, and efflux.