Age-related erosion of X chromosome inactivation in human tissues
Clarissa Rocca, Björn Gylemo, Mélise Edwards, Zam Cing, Jesse Raphael Gibbs, Colm E. Nestor, Alex R. DeCasien
The paper investigates age-related X chromosome inactivation (XCI) erosion in human females using bulk and single-cell datasets, finding age-dependent escape from XCI in specific genes.
bioRxiv · Jul 1, 2026 · PreprintBioinformatics