Julia L. Drewes

The paper creates a spatial atlas of early-stage colorectal cancer tumors to identify bacterial niches and their impact on tumor transcriptomes, highlighting C. difficile's significant influence despite low abundance.

Multi-probe imaging and 16S rRNA profiling of Malaysian colorectal cancers show that Fusobacterium nucleatum, dominated by subspecies animalis clade 2, is enriched specifically within mucus-invasive tumor biofilms.

This study maps tumor evolution and microenvironment dynamics in colorectal cancer using spatial multi-omic data, identifying key genes associated with immune exclusion and prognosis.