Björn Gylemo

The paper investigates age-related X chromosome inactivation (XCI) erosion in human females using bulk and single-cell datasets, finding age-dependent escape from XCI in specific genes.

TRiXi detects X-inactivation skewing in human DNA, revealing it as a common and stable epigenetic trait across multiple tissues and ages.

The paper determines X-inactivation status of 380 X-linked genes across 30 tissues in non-mosaic X-inactivation females, revealing new insights into X-inactivation and its implications for sex-bias in human traits.

This study identifies Y-chromosome gene functions in mouse spermatogenesis by generating Y-deletion models and analyzing gene effects on fertility.