bioRxivBioinformaticsPreprint
Age-related erosion of X chromosome inactivation in human tissues
Clarissa RoccaiD, Björn GylemoiD, Mélise Edwards, Zam Cing, Jesse Raphael GibbsiD, Colm E. NestoriD, Alex R. DeCasieniD
Abstract
Age-related diseases often show sex differences, yet their molecular bases remain unclear. Animal models suggest that age-related disruption of X-chromosome inactivation (XCI) occurs in female mice. We test whether this phenomenon extends to humans using bulk and single-cell datasets. We find that age-dependent escape from XCI also occurs in human females, particularly among genes at the distal ends of the X-chromosome and those involved in genome stability. These findings provide preliminary evidence that XCI erosion represents a human female-specific aging process.
- organism: human
- assay: bulk RNA-seq
- assay: scRNA-seq
- research focus: differential expression
- research focus: gene regulatory network inference
- approach: statistical model
- Citations
- 2
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