Zeinab Dehghani‐Ghobadi

This study shows that HNF4A maintains proximal tubule identity in adult mouse kidneys and its loss leads to injury-associated gene activation and loss of mature epithelial features.

This study shows that HNF1B is essential for maintaining proximal tubule identity in mature kidney cells and prevents activation of alternative nephron segment programs.

This study shows that constitutive Yap activation in distal nephron segments disrupts epithelial identity and nephron patterning by altering cell proliferation, lineage boundaries, and gene expression.

The paper generates a knock-in Six2Cre mouse line to study nephron progenitor potential, finding a transient contribution to the renal interstitium around embryonic day 11.