Mohammed E. Sayed

This study shows that constitutive Yap activation in distal nephron segments disrupts epithelial identity and nephron patterning by altering cell proliferation, lineage boundaries, and gene expression.

The paper generates a knock-in Six2Cre mouse line to study nephron progenitor potential, finding a transient contribution to the renal interstitium around embryonic day 11.

This study uses scRNA-seq to show that Tcf21 is essential for Foxd1+ stromal progenitor differentiation during kidney development, with loss of Tcf21 causing stromal subpopulation depletion and emergence of Emcn-expressing cells.

The paper identifies thin descending limb cells in developing mouse kidneys using scRNA-seq and shows they originate from proximal tubule cells, with Hnf4a playing a role in their development.

The paper introduces miRinGO, an R Shiny application that improves miRNA-GO term association prediction by considering indirectly targeted genes, outperforming existing methods.