Joo‐Seop Park

This study shows that HNF4A maintains proximal tubule identity in adult mouse kidneys and its loss leads to injury-associated gene activation and loss of mature epithelial features.

This study shows that HNF1B is essential for maintaining proximal tubule identity in mature kidney cells and prevents activation of alternative nephron segment programs.

This study shows that constitutive Yap activation in distal nephron segments disrupts epithelial identity and nephron patterning by altering cell proliferation, lineage boundaries, and gene expression.

The paper generates a knock-in Six2Cre mouse line to study nephron progenitor potential, finding a transient contribution to the renal interstitium around embryonic day 11.

This study uses scRNA-seq to show that Tcf21 is essential for Foxd1+ stromal progenitor differentiation during kidney development, with loss of Tcf21 causing stromal subpopulation depletion and emergence of Emcn-expressing cells.

The paper maps human kidney development using single-cell RNA sequencing and spatial transcriptomics, revealing fate decisions influenced by the local microenvironment.

The paper identifies thin descending limb cells in developing mouse kidneys using scRNA-seq and shows they originate from proximal tubule cells, with Hnf4a playing a role in their development.

This study identifies Hedgehog signaling as critical for maintaining mesenchymal nephron progenitors by inhibiting Notch signaling and upregulating Fox factors.

This study shows that interstitial Notch signaling regulates proximal tubule development in mouse kidneys through the Gata3-Renin axis.

This study shows Hnf4a is essential for Cdh6-expressing progenitors to develop into proximal tubules in the mouse kidney by regulating genes involved in reabsorption.

This study shows that Wnt/β-catenin signaling is critical for the development of multiple nephron segments in mice.