SALL2 constrains TEAD4 by maintaining repressive chromatin to restrict trophectoderm identity
Yu Qiao, Jianfei Xu, Lin Zheng, Zhen Xiao, Zhuoqi Huang, Zhangting Liang, Xuemeng Zhou, Gang Ma, Guoqing Tong, Miguel Angel Esteban, Andrew P. Hutchins
This study shows SALL2 restricts trophectoderm identity by maintaining repressive chromatin at TEAD4-bound loci, preventing TE lineage commitment in human pluripotent stem cells.
bioRxiv · Jul 10, 2026 · PreprintCell Biology