This study shows SALL2 restricts trophectoderm identity by maintaining repressive chromatin at TEAD4-bound loci, preventing TE lineage commitment in human pluripotent stem cells.

bioRxiv · Jul 10, 2026 · PreprintCell Biology

Transposable Element Expression and Sub-cellular Dynamics During hPSC Differentiation to Endoderm, Mesoderm, and Ectoderm Lineages

Isaac A. Babarinde, Xiuling Fu, Gang Ma, Yuhao Li, Zhangting Liang, Jianfei Xu, Zhen Xiao, Yu Qiao, Lin Zheng, Katerina Oleynikova, Mobolaji T. Akinwole, Xuemeng Zhou, Alexey S. Ruzov, Andrew P. Hutchins

This study examines TE expression and sub-cellular dynamics during hPSC differentiation to endoderm, mesoderm, and ectoderm lineages, revealing lineage-specific TE expression patterns and chromatin associations.

Nature Communications · Aug 18, 2025Peer-reviewedGenomics

Thioredoxin-1 inhibits granulosa cell ferroptosis to rescue ovarian aging through mitophagy-dependent activation of BNIP3L

Wenting Yang, Xiaorui Zhang, Rui Xu, Zhuoqi Huang, Yanmin Ma, Jiao Yang, Lin Zheng, Gang Ma, Jianfei Xu, Yu Qiao, Zhen Xiao, Jing Cao, Shan Li, Xinyu Zhang, Andrew P. Hutchins, Guoqing Tong

This study shows that Thioredoxin-1 prevents granulosa cell ferroptosis by promoting mitophagy, thereby improving ovarian aging and fertility in mice.

bioRxiv · Jul 12, 2025 · PreprintCell Biology