Optimizing broadly neutralizing antibodies via all-atom interaction modeling and pre-trained language models
Yidong Song, Fandi Wu, Rubo Wang, Wei Zheng, Bing He, Qihong Yan, Xiaohan Huang, Yuquan Li, Sheng Chen, Qianmu Yuan, Jiahua Rao, Zhenchao Tang, Jiale Zhou, Haohuai He, Jincun Zhao, , Jianhua Yao
This paper introduces InterAb and InterAb-Opt, computational frameworks that predict and optimize broadly neutralizing antibodies using all-atom modeling and pre-trained language models, showing significant improvements in binding affinity and neutralization activity.
bioRxiv · Aug 7, 2026 · PreprintBioinformatics