Jun Zhu

Genetic-to-chemical perturbation transfer learning through unified multimodal molecular representations

UniPert-G2CP transfers genetic perturbation insights to chemical perturbation modeling, enabling efficient in silico drug screening with reduced data costs.

LARP4 is a B cell-specific metabolic checkpoint for plasma cell differentiation and a therapeutic target in systemic lupus erythematosus

Regional analysis of spatiotemporal trends in Colorado potato beetle abundance

The paper analyzes spatiotemporal trends in Colorado potato beetle abundance using multi-year scouting data and climate factors to improve pest management predictions.

MolSpecFlow: Mass-Constrained Hybrid Flow Matching for Joint Molecular-Spectral Analysis

MolSpecFlow bridges the gap between molecules and mass spectra using a hybrid flow matching model, achieving state-of-the-art results in de novo generation and spectral simulation.

In vivo AAV9-SB-CRISPR screen identifies fatty acid elongase ELOVL5 as a pro-resolving mediator in lung inflammation

Defining the transcriptional landscape of infiltrating immune cells in human and mouse bladder cancer.

This study maps immune cell transcriptional profiles in human and mouse bladder tumors to identify conserved and divergent gene expression patterns and immune cell interactions.

Gene Expression Elucidates Functional Impact of Polygenic Risk for Schizophrenia

The paper uses gene expression data from schizophrenia cases and controls to show that common variants at 20% of schizophrenia risk loci regulate brain gene expression, with functional impacts on neural progenitor cells and zebrafish neuroanatomy.