Reconstruct a eukaryotic chromosome arm by de novo design and synthesis
Shuangying Jiang, Zhouqing Luo, Yu Kang, Shijun Zhao, Zelin Cai, Wenfei Yu, Hui Wang, Li Cheng, Zhenzhen Liang, Hui Gao, Marco Monti, Daniel Schindler, Linsen Huang, Cheng Zeng, Weimin Zhang, , Junbiao Dai
This paper designs and synthesizes a functional neochromosome in yeast that replaces a native chromosome arm, demonstrating genome plasticity and synthetic chromosome viability.
bioRxiv · Oct 4, 2022 · PreprintSynthetic Biology