Marco Monti

The paper engineers an essential neo-chromosome III in yeast to enable genome minimisation by relocating essential genes, demonstrating stability and cross-species complementation.

This study demonstrates that genomic rearrangements in yeast can be efficiently induced using SCRaMbLE, leading to diverse genetic changes and phenotypic effects.

This paper designs and synthesizes a functional neochromosome in yeast that replaces a native chromosome arm, demonstrating genome plasticity and synthetic chromosome viability.