Author

Zhiyu Shu

Nanyang Technological University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Assay:DNA methylation· 2 Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

Fangyu ZhouiD· 2 shared Gang CheniD· 2 shared Anni Wang· 1 shared Cheng JiangiD· 1 shared Chi XiongiD· 1 shared Dongmei SuniD· 1 shared Goran StjepanovićiD· 1 shared Gui‐Juan ChengiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersBiophysics

Fangyu ZhouORCID

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2 papers

Recent·Most cited

Dangling Ends of Third Strand and Duplex Drive Nucleic Acid Triplex Stabilization through Bimodal Association

Fangyu Zhou, Yiran Liu, Zhiyu Shu, Yongqiang Wang, Gang Chen

This paper investigates triplex stability by showing that dangling ends from both the third strand and duplex enhance stability through bimodal association kinetics.

bioRxiv · Nov 2, 2025 · PreprintBiophysics

Enhanced Recognition of a Herbal Compound Epiberberine by a DNA Quadruplex-Duplex Structure

Xuan Zhan, Liping Deng, Yun Lian, Zhiyu Shu, Yunong Xu, Xinyi Mai, Manchugondanahalli S. Krishna, Rongguang Lu, Anni Wang, Shiyao Bai, Fangyu Zhou, Chi Xiong, Yingyi Xu, Jie Ni, J. Jeya Vandana, , Gang Chen

This paper investigates how epiberberine binds to a DNA quadruplex structure and shows how modifying the DNA structure enhances binding affinity, leading to a new method for extracting the compound from plant extracts.

Analytical Chemistry · Aug 2, 2024Peer-reviewedBiochemistry