Xuan Zhan

This paper introduces a dual-affinity PNA (daPNA) platform that targets miR-21 precursor, inhibits Dicer activity, and rescues PTEN expression by blocking miR-21 maturation.

This paper investigates how modifying PNA with s2U adjacent to Q residues enhances binding affinity and functional activity toward dsRNAs, demonstrating broader applicability in targeting structured RNA structures.

This paper introduces daPNAs, a programmable platform combining dbPNAs and asPNAs to target RNA junctions, demonstrating their use in inhibiting Dicer and regulating ribosomal frameshifting.

This paper investigates how epiberberine binds to a DNA quadruplex structure and shows how modifying the DNA structure enhances binding affinity, leading to a new method for extracting the compound from plant extracts.