Author

Yun Lian

Chinese University of Hong Kong, Shenzhen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Molecular Biology· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1

Frequent Co-Authors

Gang CheniD· 5 shared Rongguang LuiD· 5 shared Manchugondanahalli S. KrishnaiD· 4 shared Xuan ZhaniD· 4 shared Hanting Zhou· 3 shared Ruiyu Lin· 3 shared Shijian Fan· 3 shared Yanyu CheniD· 3 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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5 shared papersBiochemistry

Gang ChenORCID

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Author profile →

5 papers

Recent·Most cited

A programmable mRNA platform for miRNA detection via miRNA-mRNA2 triplex-mediated ribosomal frameshifting

Yanyu Chen, Wanqi Zhao, Huizhen Chen, Hanting Zhou, Shijian Fan, Liping Xing, Yun Lian, Hongyu Duan, Yuze Dai, Zheng Zhao, Rongguang Lu, Chenzhong Li, Cheng Jiang, Ho Yin Edwin Chan, Gang Chen

This paper develops a programmable mRNA platform that detects specific miRNAs by converting their presence into a quantifiable protein output through miRNA-triggered ribosomal frameshifting.

ACS Synthetic Biology · Jul 17, 2026Peer-reviewedSynthetic Biology

A new dual-affinity peptide nucleic acid for targeting miRNA-21 precursor rescues tumor repressor PTEN expression

Yun Lian, Anni Wang, Ruiyu Lin, Xin Ke, Xuan Zhan, Rongguang Lu, Tingli Qian, Arpita Ghosh, Alan Ann Lark Ong, Desiree‐Faye Kaixin Toh, Kiran M. Patil, Manchugondanahalli S. Krishna, Clément Dezanet, Jean‐Luc Décout, Souvik Maiti, , Gang Chen

This paper introduces a dual-affinity PNA (daPNA) platform that targets miR-21 precursor, inhibits Dicer activity, and rescues PTEN expression by blocking miR-21 maturation.

Cell Reports Physical Science · Nov 1, 2025Peer-reviewedMolecular Biology

Towards the Development of Isoenergetic Peptide Nucleic Acid Based Probes Targeting Double-Stranded RNAs Through Enhancing Sequence-Specific Stacking Interactions

Rongguang Lu, Kun Xi, Ruiyu Lin, Manchugondanahalli S. Krishna, Yanyu Chen, Xuan Zhan, Honghao Zeng, Xue Li, Shijian Fan, Hanting Zhou, Wenzheng Wu, Yun Lian, Yuze Dai, Lizhe Zhu, Guobao Li, Gang Chen

This paper investigates how modifying PNA with s2U adjacent to Q residues enhances binding affinity and functional activity toward dsRNAs, demonstrating broader applicability in targeting structured RNA structures.

bioRxiv · Jun 28, 2025 · PreprintBiochemistry

Recognition of RNA secondary structures with a programmable peptide nucleic acid-based platform

Rongguang Lu, Liping Deng, Yun Lian, Xin Ke, Lixia Yang, Kun Xi, Alan Ann Lerk Ong, Yanyu Chen, Hanting Zhou, Zhenyu Meng, Ruiyu Lin, Shijian Fan, Yining Liu, Desiree‐Faye Kaixin Toh, Xuan Zhan, , Gang Chen

This paper introduces daPNAs, a programmable platform combining dbPNAs and asPNAs to target RNA junctions, demonstrating their use in inhibiting Dicer and regulating ribosomal frameshifting.

Cell Reports Physical Science · Aug 12, 2024Peer-reviewedBiochemistry

Enhanced Recognition of a Herbal Compound Epiberberine by a DNA Quadruplex-Duplex Structure

Xuan Zhan, Liping Deng, Yun Lian, Zhiyu Shu, Yunong Xu, Xinyi Mai, Manchugondanahalli S. Krishna, Rongguang Lu, Anni Wang, Shiyao Bai, Fangyu Zhou, Chi Xiong, Yingyi Xu, Jie Ni, J. Jeya Vandana, , Gang Chen

This paper investigates how epiberberine binds to a DNA quadruplex structure and shows how modifying the DNA structure enhances binding affinity, leading to a new method for extracting the compound from plant extracts.

Analytical Chemistry · Aug 2, 2024Peer-reviewedBiochemistry