Author

Zhongsheng Zhang

University of Washington

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Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1

Frequent Co-Authors

Ben ShoriD· 1 shared Clinton YuiD· 1 shared Dina Schneidman‐DuhovnyiD· 1 shared Erkang FaniD· 1 shared Fenglong JiaoiD· 1 shared Haibin MaoiD· 1 shared Huigang ShiiD· 1 shared Lan HuangiD· 1 shared

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2026-2026 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperMolecular Biology

Ben ShorORCID

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1 paper

Recent·Most cited

Orthosteric Molecular Glue Inhibits COP9 Signalosome with Substrate-Dependent Potency

Huigang Shi, Xiaorong Wang, Clinton Yu, Haibin Mao, Fenglong Jiao, Merav Braitbard, Ben Shor, Zhongsheng Zhang, Thomas Richard Hinds, Shiyun Cao, Erkang Fan, Dina Schneidman‐Duhovny, Lan Huang, Ning Zheng

This paper shows that an orthosteric inhibitor of the COP9 signalosome achieves high potency through a molecular glue mechanism that enhances substrate-dependent binding.

Nature · Feb 11, 2026Peer-reviewedMolecular Biology