Ben Shor

This paper shows that an orthosteric inhibitor of the COP9 signalosome achieves high potency through a molecular glue mechanism that enhances substrate-dependent binding.

DockFormer predicts protein-small molecule binding affinity and structure using a flexible docking approach, outperforming existing methods on benchmark datasets.

The paper introduces CombFold, a method that uses AlphaFold2 to predict large protein complexes with high accuracy, achieving 72% success in Top-10 predictions and improved structural coverage.