Author

Xiaorong Wang

University of California, IrvineORCID 0000-0002-9332-9571Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Xiaorong Wang1 paper

Biology Disciplines

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Molecular Biology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Clinton YuiD· 2 shared Lan HuangiD· 2 shared Alfred Lewis GoldbergiD· 1 shared Ang LuoiD· 1 shared Ben ShoriD· 1 shared Cindy Y. How· 1 shared Dina Schneidman‐DuhovnyiD· 1 shared Dong Hoon LeeiD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersMolecular Biology

Clinton YuORCID

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Author profile →

3 papers

Recent·Most cited

Orthosteric Molecular Glue Inhibits COP9 Signalosome with Substrate-Dependent Potency

Huigang Shi, Xiaorong Wang, Clinton Yu, Haibin Mao, Fenglong Jiao, Merav Braitbard, Ben Shor, Zhongsheng Zhang, Thomas Richard Hinds, Shiyun Cao, Erkang Fan, Dina Schneidman‐Duhovny, Lan Huang, Ning Zheng

This paper shows that an orthosteric inhibitor of the COP9 signalosome achieves high potency through a molecular glue mechanism that enhances substrate-dependent binding.

Nature · Feb 11, 2026Peer-reviewedMolecular Biology

Crosslinking-mediated Interactome Analysis Identified PHD2-HIF1α Interaction Hotspots and the Role of PHD2 in Regulating Protein Neddylation

Haiping Ouyang, Cindy Y. How, Xiaorong Wang, Clinton Yu, Ang Luo, Lan Ji Huang, Yue Chen

This study identifies PHD2 interaction hotspots and reveals its role in regulating protein neddylation through interaction with the COP9 Signalosome complex.

bioRxiv · Dec 16, 2024 · PreprintBiochemistry

Molecular mechanisms for activation of the 26S proteasome

Dong Hoon Lee, Yanan Zhu, Louis Colson, Xiaorong Wang, Si-Yi Chen, Emre Tkacik, Lan Huang, Qi Ouyang, Alfred Lewis Goldberg, Ying Lu

The paper investigates how ZFAND5 activates the 26S proteasome by inducing conformational changes that enhance substrate degradation.

bioRxiv · May 9, 2023 · PreprintMolecular Biology