Huigang Shi

The paper identifies single amino acid mutations that create functional degrons in transcription factors, enabling targeted protein degradation and revealing a new mechanism for disease-related protein turnover.

This paper shows that an orthosteric inhibitor of the COP9 signalosome achieves high potency through a molecular glue mechanism that enhances substrate-dependent binding.

This study reveals how two F-box proteins, FBXO22 and FBXL17, recognize distinct structural features of the BACH1 BTB dimer under oxidative stress, leading to its ubiquitination and degradation.