Tomosyns attenuate SNARE assembly and synaptic depression by binding to VAMP2-containing template complexes
Marieke Meijer, Miriam Öttl, Jie Yang, Aygul Subkhangulova, Avinash Kumar, Zicheng Feng, Torben W. van Voorst, Alexander J. A. Groffen, Jan R.T. van Weering, Yongli Zhang, Matthijs Verhage
This study shows tomosyns inhibit synaptic depression by binding to VAMP2-containing template complexes and preventing SNAP-25 association, rather than competing with VAMP2 for SNARE complex assembly.
Nature Communications · Mar 26, 2024Peer-reviewedNeuroscience