Author

Alexander J. A. Groffen

Amsterdam University Medical CentersORCID 0000-0003-0046-4027Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cell signaling & trafficking· 1 Assay:electrophysiology· 1

Frequent Co-Authors

Aygul SubkhangulovaiD· 2 shared Jan R.T. van WeeringiD· 2 shared Matthijs VerhageiD· 2 shared August Benjamin SmitiD· 1 shared Avinash KumariD· 1 shared Jie YangiD· 1 shared Marieke MeijeriD· 1 shared Matthijs Verhage· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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2 shared papersNeuroscience

Aygul SubkhangulovaORCID

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3 papers

Recent·Most cited

NeuroscienceNature CommunicationsPeer-reviewedMar 26, 2024

Tomosyns attenuate SNARE assembly and synaptic depression by binding to VAMP2-containing template complexes

Marieke Meijer, Miriam Öttl, Jie Yang…·Matthijs Verhage

This study shows tomosyns inhibit synaptic depression by binding to VAMP2-containing template complexes and preventing SNAP-25 association, rather than competing with VAMP2 for SNARE complex assembly.

5 citations

mouseexperimental assay

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NeuroscienceeLifePeer-reviewedAug 29, 2023

SNARE protein tomosyn regulates dense core vesicle composition but not exocytosis in mammalian neurons

Aygul Subkhangulova, Miguel A. Gonzalez‐Lozano, Alexander J. A. Groffen…·Matthijs Verhage

This study shows that tomosyn regulates DCV cargo levels but not exocytosis in neurons, suggesting a role in cargo production rather than release.

6 citations

mouseexperimental assay

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Cell BiologybioRxivPreprintJan 31, 2019

Doc2b Ca2+-binding site mutants act as a gain of function at rest and loss of function during neuronal activity

Quentin Bourgeois-Jaarsma, Matthijs Verhage, Alexander J. Groffen

DOI 10.1101/536581

mouseelectrophysiology

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