Jie Yang

This study identifies P2x2 receptor upregulation in the cochlea as a cause of hyperacusis, showing that antagonists can reduce hearing hypersensitivity.

This paper introduces genetically encoded mechano-sensors using coiled coils to measure mechanical forces in vivo with diverse readouts and compact design.

This study shows tomosyns inhibit synaptic depression by binding to VAMP2-containing template complexes and preventing SNAP-25 association, rather than competing with VAMP2 for SNARE complex assembly.

The paper shows Munc13-1 directly binds SNAP25 to initiate SNARE complex assembly, using FRET and optical tweezer techniques.

The paper uses super-resolution fluorescence imaging to reveal periodic CB1 receptor clusters in neurons and their interaction with the MPS.