Michelle Kim

Stage-specific exposure to an activity-permissive media enhances neuronal maturation in oligodendrocyte-enriched cortical organoids

This study shows that exposing oligodendrocyte-enriched cortical organoids to a specific medium during development enhances neuronal activity and maturation while preserving oligodendrocyte development.

Synchronized long-read genome, methylome, epigenome, and transcriptome for resolving a Mendelian condition

Pooling Fiber-seq gDNA with concatenated MAS-Seq cDNA in one PacBio run gives phased genome, methylome, chromatin, and transcriptome, exposing four gene disruptions from one X;13 translocation.

Changes in gut microbiome composition drive fentanyl intake and striatal proteomic changes

This study shows that changes in gut microbiome composition influence fentanyl intake and striatal proteomic changes in a drug self-administration model.

Causal effects on complex traits are similar across segments of different continental ancestries within admixed individuals

The paper quantifies similarity in causal effects across local ancestries in admixed individuals and finds high genetic correlation (radmix=0.95) within individuals.