An engineered nanobody inhibitor for molecular-to-circuit control of opioid receptor function
Zoé Valbret, Paul J. Lamothe‐Molina, Sofia Papadogkonaki, Antoine Koehl, Jan Vincent V. Arafiles, Ziva Shapiro Tuchman, Nicole M. Fisher, Arthur Radoux-Mergault, Annika Canziani, Gaoyang Huang, Mark von Zastrow, Mickey Kosloff, Christian P. R. Hackenberger, Aashish Manglik, Tommaso Patriarchi, Miriam Stoeber
This paper develops an engineered nanobody inhibitor to control opioid receptor function with subcellular precision and demonstrates its effectiveness in vivo.
bioRxiv · Jan 14, 2026 · PreprintNeuroscience