Paul J. Lamothe‐Molina

PinkyCaMP a mScarlet-based calcium sensor with exceptional brightness, photostability, and multiplexing capabilities

The paper introduces PinkyCaMP, a new red fluorescent calcium sensor with improved brightness, photostability, and compatibility with optogenetics and neurotransmitter imaging.

An engineered nanobody inhibitor for molecular-to-circuit control of opioid receptor function

This paper develops an engineered nanobody inhibitor to control opioid receptor function with subcellular precision and demonstrates its effectiveness in vivo.

Epigenetic repression of cFos supports sequential formation of distinct spatial memories

The paper investigates how {Delta}FosB inhibition affects cFos expression and memory formation, finding that epigenetic repression of cFos supports sequential spatial memory formation.

Neuronal FOS reports synchronized activity of presynaptic neurons

The paper investigates the relationship between neuronal spiking frequency and FOS expression in hippocampal neurons, finding that FOS expression is cell-type specific, frequency-dependent, and not cell-autonomous.

Freeze-frame imaging of dendritic calcium signals with TubuTag

This paper introduces TubuTag, a genetically encoded calcium sensor for imaging dendritic calcium signals in neurons with high temporal and spatial resolution.

cFos ensembles in the dentate gyrus rapidly segregate over time and do not form a stable map of space

The paper shows that cFos expression in the dentate gyrus changes daily and does not stabilize with spatial memory, yet neurons from early training days still influence later performance.

Freeze-frame imaging of synaptic activity using SynTagMA

The paper introduces SynTagMA, a tool to mark active synapses in a 2-second window, and provides software for analyzing large datasets of synaptic activity.