LRRC58 defines an E3 ubiquitin ligase complex sensitive to cysteine abundance
Dylan E. Ramage, Lianne H. E. Wieske, Charlotte Crowe, Jens Bager Christensen, Theo A. von Wilmowski, Zoe Bannister, Drew W. Grant, Mark A. Nakasone, Kevin Haubrich, Mark Dorward, Iva A. Tchasovnikarova, Michael P. Weekes, Nicholas J. Matheson, N. Sumru Bayin, Alessio Ciulli, Richard T. Timms
The paper identifies LRRC58 as a substrate adaptor in a Cul2 E3 ligase complex that regulates CDO1 degradation in response to cysteine availability, preventing ferroptosis and neurodevelopmental defects.
Molecular Cell · Jun 19, 2026Peer-reviewedMolecular Biology