Author

Lianne H. E. Wieske

University of DundeeORCID 0000-0003-4617-7605Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Approach:statistical model· 1

Frequent Co-Authors

Alessio CiulliiD· 2 shared Charlotte CroweiD· 2 shared Drew W. GrantiD· 1 shared Dylan E. RamageiD· 1 shared Iva A. TchasovnikarovaiD· 1 shared Jens Bager ChristenseniD· 1 shared Kevin HaubrichiD· 1 shared Louise M. SternickiiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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2 shared papersBiophysics

Alessio CiulliORCID

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2 papers

Recent·Most cited

BiophysicsAnalytical ChemistryPeer-reviewedJun 30, 2026

Native Mass Spectrometry Analysis of Cullin RING Ubiquitin E3 Ligase Complexes in the Context of Targeted Protein Degradation

Louise M. Sternicki, Charlotte Crowe, Lianne H. E. Wieske…·Sally‐Ann Poulsen

This study uses native mass spectrometry to characterize CRL2VHL complexes and their interactions with PROTACs and POIs, revealing key multiprotein assemblies involved in targeted protein degradation.

1 citation

experimental assayhost-pathogen & immune response

𝕏 PostBluesky

Molecular BiologyMolecular CellPeer-reviewedJun 19, 2026

LRRC58 defines an E3 ubiquitin ligase complex sensitive to cysteine abundance

Dylan E. Ramage, Lianne H. E. Wieske, Charlotte Crowe…·Richard T. Timms

The paper identifies LRRC58 as a substrate adaptor in a Cul2 E3 ligase complex that regulates CDO1 degradation in response to cysteine availability, preventing ferroptosis and neurodevelopmental defects.

6 citationstop 1%

humanstatistical model

𝕏 PostBluesky