The GINS complex is required for the survival of rapidly proliferating retinal and tectal progenitor cells during zebrafish development
Máté Varga, Kitti Csályi, István Bertyák, Dóra K. Menyhárd, Richard J. Poole, Kara L. Cerveny, Dorottya Kövesdi, Balázs Barátki, Hannah Rouse, Zsuzsa Vad, Thomas A. Hawkins, Heather L. Stickney, Florencia Cavodeassi, Quenten Schwarz, Rodrigo Young, Stephen W. Wilson
This study shows that the GINS complex is essential for DNA replication in rapidly dividing retinal and tectal progenitor cells in zebrafish, leading to apoptosis in these cells when GINS function is absent.
bioRxiv · Feb 9, 2020 · PreprintGenetics