Contractile perinuclear actomyosin network promotes peripheral and polar chromosome interaction with the mitotic spindle
Nooshin Sheidaei, John K. Eykelenboom, Zuojun Yue, Graeme Ball, Alexander JR Booth, Tomoyuki U Tanaka
The paper shows that PANEM contraction repositions peripheral and polar chromosomes to enhance their interaction with the mitotic spindle, ensuring correct segregation and reducing chromosomal instability in cancer cells.
eLife · Jun 11, 2026Peer-reviewedCell Biology