Tomoyuki U Tanaka

The paper shows that PANEM contraction repositions peripheral and polar chromosomes to enhance their interaction with the mitotic spindle, ensuring correct segregation and reducing chromosomal instability in cancer cells.

This study shows that excluding condensin I from the nucleus during prophase allows condensin II to complete sister chromatid resolution, ensuring correct chromosome segregation.

Elraglusib causes cytotoxicity by directly destabilizing microtubules, leading to mitotic arrest, DNA damage, and apoptosis, independent of GSK3 inhibition.

This study reveals the unidirectional chloride transport mechanism in NM-R3 using TR-SFX, showing conformational changes and halide binding site insights.