Yiyuan Liu

Cytokine-induced reprogramming of human macrophages toward Alzheimer's disease-relevant molecular and cellular phenotypes in vitro

This study reprograms human macrophages in vitro using cytokines to mimic Alzheimer's disease-relevant phenotypes, showing transcriptomic and functional changes similar to disease-associated microglia.

Upregulated GIRK2 counteracts ethanol-induced changes in excitability and respiration in human neurons

The paper investigates how upregulated GIRK2 affects ethanol-induced changes in human neurons, showing it counteracts excitability and respiration changes.

BHLHE40/41 regulate macrophage/microglia responses associated with Alzheimer's disease and other disorders of lipid-rich tissues

This study identifies BHLHE40/41 as key regulators of macrophage/microglia responses in Alzheimer's disease and other lipid-rich tissue disorders through sc/nRNA-seq analysis and functional validation.

Glutamatergic dysfunction precedes neuron loss in cerebral organoids with MAPT mutation.

This study shows that glutamatergic dysfunction occurs before neuron loss in cerebral organoids with MAPT mutations, suggesting therapeutic targets for FTD.

KLF4 is involved in the organization and regulation of pluripotency-associated 3D enhancer networks

This study investigates the role of KLF4 in chromatin reorganization and 3D enhancer rewiring during reprogramming of mouse embryonic fibroblasts to pluripotent stem cells.