Rita Berisio

This study presents the first crystal structure of HtpGMtb, revealing a conformationally silent dimer and direct TLR4 interaction, providing insights into its catalytic activity and TLR4 activation mechanism.

The paper catalogs 105 recombinant Klebsiella phage depolymerases, classifying them by sequence, structure, and substrate specificity, revealing diverse enzyme functions and evolutionary patterns.

The paper develops a self-assembling peptide antigen, Q11-EH, that elicits broad-spectrum opsonic antibodies against multiple Gram-positive pathogens.

This study identifies cross-reactive vaccine antigens in Gram-positive ESKAPE pathogens using subtractive proteome analysis and opsonic activity testing.

This paper identifies Rv3284 (SufEMtb) as a new activator of Mtb's SseA enzyme, revealing a regulatory mechanism that could be targeted for tuberculosis therapy.

This paper presents the crystal structure and molecular dynamics simulations of KCTD1 and its P20S mutant, revealing structural insights into its function and disease mechanisms.