Alessia Ruggiero

This study presents the first crystal structure of HtpGMtb, revealing a conformationally silent dimer and direct TLR4 interaction, providing insights into its catalytic activity and TLR4 activation mechanism.

This paper identifies Rv3284 (SufEMtb) as a new activator of Mtb's SseA enzyme, revealing a regulatory mechanism that could be targeted for tuberculosis therapy.

This paper presents the crystal structure and molecular dynamics simulations of KCTD1 and its P20S mutant, revealing structural insights into its function and disease mechanisms.

The paper identifies a Y-linked gene, MoY, essential for male sex determination in medflies and shows its conservation across multiple fruit fly species, enabling potential genetic control strategies.