Author

Samantha A. Spencer

Virginia Commonwealth UniversityORCID 0000-0001-5048-1736Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:zebrafish· 2 Research Focus:cell-cell communication· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:gene regulatory network inference· 1 Organism:mouse· 1

Frequent Co-Authors

Alessandra M. Larimer-PiccianiiD· 1 shared Anirban PauliD· 1 shared Aron E. LukacheriD· 1 shared Arrienne B. ButiciD· 1 shared ChaeMin KimiD· 1 shared Elia AfanasieviD· 1 shared Elizabeth A. ProctoriD· 1 shared Ge Jin· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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1 shared paperDevelopmental Biology

Alessandra M. Larimer-PiccianiORCID

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3 papers

Recent·Most cited

ImmunologyDOAJ (DOAJ: Directory of Open Access Journals)Peer-reviewedAug 17, 2026

PD-1 regulates CD4+ T cell-mediated CD8+ T cell responses in the brain to balance viral control and neuroinflammation

Arrienne B. Butic, Elia Afanasiev, Samantha A. Spencer…·Aron E. Lukacher

This study shows PD-1 in CD4+ T cells balances antiviral defense and neuroinflammation during polyomavirus CNS infection by modulating CD8+ T cell responses.

DOI 10.1038/s41467-026-76762-3

mousescRNA-seq

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Developmental BiologyPLoS ONEPeer-reviewedJan 13, 2021

The MITF paralog tfec is required in neural crest development for fate specification of the iridophore lineage from a multipotent pigment cell progenitor

Kleio Petratou, Samantha A. Spencer, Robert Neil Kelsh, J. A. Lister

This study identifies Tfec as the master regulator of iridophore fate specification from multipotent neural crest progenitors in zebrafish, revealing its role in early pigment cell lineage decisions.

55 citations

zebrafishstatistical model

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Developmental BiologyDevelopmentPeer-reviewedJan 1, 2020

Mitf-family transcription factor function is required within cranial neural crest cells to promote choroid fissure closure

Katie L. Sinagoga, Alessandra M. Larimer-Picciani, Stephanie M. George…·Jeffrey M. Gross

The paper shows that Mitf-family transcription factors are required in cranial neural crest cells to promote choroid fissure closure and that their absence causes colobomas.

13 citations

zebrafishexperimental assay

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