Elia Afanasiev

PD-1 regulates CD4+ T cell-mediated CD8+ T cell responses in the brain to balance viral control and neuroinflammation

This study shows PD-1 in CD4+ T cells balances antiviral defense and neuroinflammation during polyomavirus CNS infection by modulating CD8+ T cell responses.

found: Inferring cell-level perturbation from structured label noise in single-cell data

The paper introduces found, a tool implementing HiDDEN for cell-level perturbation analysis, showing performance depends on modeling choices.

Cerebrospinal fluid-driven ependymal motile cilia defects are implicated in multiple sclerosis pathophysiology

This study investigates ependymal cilia dysfunction in multiple sclerosis, finding dysregulated ciliary genes and impaired ciliary function in MS patients and animal models.

A rewiring of the earliest immune events leading to T-cell mediated disease following intestinal infection in a PINK1 knock out mouse model of Parkinsons disease

This study identifies early immune dysregulation in PINK1 KO mice following intestinal infection, showing myeloid cell activation and T cell response as key factors in PD-like disease progression.

An MRI-informed histo-molecular analysis implicates ependymal cells in the pathogenesis of periventricular pathology in multiple sclerosis

The paper uses multiomic single nucleus RNA/ATAC sequencing to show ependymal cell dysregulation correlates with periventricular pathology in MS and identifies IFNγ as a driver.

An integrative layer-resolved atlas of the adult human meninges

This study creates the first layer-resolved atlas of the adult human meninges using single-cell RNA sequencing, MERFISH, and immunolabeling, identifying 10 fibroblast subpopulations and novel interactions in the dura and subarachnoid space.

Senolytic treatment depletes microglia and decreases severity of experimental autoimmune encephalomyelitis.

This study shows that senolytic treatment reduces microglia and alleviates EAE symptoms in mice, suggesting senescent glia contribute to neuroinflammation.