Author

Aron E. Lukacher

Pennsylvania State UniversityORCID 0000-0002-7969-2841Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Ge Jin· 2 shared Kalynn M AlexanderiD· 2 shared Katelyn Nicole AyersiD· 2 shared Matthew D. LauveriD· 2 shared Alyssa OchettoiD· 1 shared Anirban PauliD· 1 shared Arrienne B. ButiciD· 1 shared ChaeMin KimiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersImmunology

Ge Jin

Mutual co-authors in cluster

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2 papers

Recent·Most cited

PD-1 regulates CD4+ T cell-mediated CD8+ T cell responses in the brain to balance viral control and neuroinflammation

Arrienne B. Butic, Elia Afanasiev, Samantha A. Spencer, Mofida Abdelmageed, Anirban Paul, Kalynn M Alexander, Katelyn Nicole Ayers, Todd D. Schell, Matthew D. Lauver, Ge Jin, Samantha M. Borys, Rachel Y. Kang, ChaeMin Kim, Elizabeth A. Proctor, Laurent Brossay, , Aron E. Lukacher

This study shows PD-1 in CD4+ T cells balances antiviral defense and neuroinflammation during polyomavirus CNS infection by modulating CD8+ T cell responses.

DOAJ (DOAJ: Directory of Open Access Journals) · Aug 17, 2026Peer-reviewedImmunology

The CD4 T cell-independent IgG response during persistent virus infection favors emergence of neutralization-escape variants

Katelyn Nicole Ayers, Matthew D. Lauver, Kalynn M Alexander, Ge Jin, Kitt D. Paraiso, Alyssa Ochetto, Sonal Garg, Daniel J. Goetschius, Susan L. Hafenstein, Joseph Che‐Yen Wang, Aron E. Lukacher

Pre-existing and acquired CD4 T cell deficiency facilitates outgrowth of Ab-escape viral variants during persistent infection.

bioRxiv · Dec 22, 2024 · PreprintImmunology